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NEW
Introducing The Twist PCR-Free WGS Library Preparation Kit
Power your sequencing with Twist’s enzyme driven library prep; engineered to deliver more data from your sample.
Confidence When Every Read Counts
Confidence in every read separates signal from noise. Missed exons, biased fragments, or uneven coverage can hide critical variants, transcripts, or methylation sites. Twist delivers integrated fragmentation-to-enrichment solutions that maintain consistency and clarity across your entire sequencing workflow
- Focuses sequencing on key regions for meaningful depth.
- Cuts excess sequencing and analysis to lower cost and data load.
- Improves sensitivity for low allele frequency variants.
- Supports tailored panels for specific pathways or research goals.
Why Target with Twist
Target enrichment workflows with Twist deliver scalable, low bias, and highly uniform coverage across large and complex genomic regions; enabling broader discovery, higher sensitivity, and greater flexibility than amplicon or array based methods.
Twist Target EnrichmentNGS Method |
Amplicon SequencingNGS Method |
Array-Based AnalysisNGS Method |
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| Design Method | Fully customizable panels | Fixed amplicons; redesign requires new primers | Fixed content; no new targets |
| Performance traits | Uniform coverage, even in GC-rich regions | Uneven due to PCR bias | Limited to preset markers |
| Variant classes | Detects SNVs, indels, CNVs, fusions, isoforms | Good for small SNVs; poor for complex variants | Only known variants |
| Throughput / Format | Scales from small to million-probe panels | Hard to scale large panels | Must buy new arrays for expansion |
| View offerings |
How it works
Target Enrichment Sequencing Workflow
Target enrichment selectively captures the regions that matter; genes, exons, splice sites, or CpG islands; focusing sequencing power for deeper coverage, fewer wasted reads, and faster results.
Why choose us
Complete your Target
Enrichment Workflow
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What we offer
Featured Solutions
Standard Hyb Kit
HybridizationStandard Hyb delivers fast, efficient, uniform capture with strong on-target rates across panel sizes.
Exome 2.0
PanelsTwist Exome 2.0 is designed to detect rare and inherited diseases, as well as germline cancers.
Human Methylome Panel
PanelsThe Twist Human Methylome Panel targets 3.98M CpG sites through 123 Mb of genomic content to target biologically relevant methylation markers.
Custom Panels
PanelsCustom Panels provide fully tailored probe designs with uniform capture for precise, application-specific coverage.
RNA Exome
PanelsThe Twist RNA Exome provides a reliable tool for generating transcriptome sequencing data from RNA.
Twist Bioscience HQ
681 Gateway Blvd
South San Francisco, CA 94080
